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KMID : 0379520030190040321
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한국독성학회지
2003 Volume.19 No. 4 p.321 ~ p.324
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Antigenicity Study on IDC7181, a Quaternary Ammoniopropenyl Cephalosporin Possessing Two Vinyl Groups
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Sin Ji-Soon
Zhang Hu-Song
Choi Ehn-Kyoung
Kwon Woon
Chai Hee-Youl
Cho Young-Min
Kim Yun-Bae
Kang Jong-Koo
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Abstract
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Antigenic potential of a novel cephalosporin, IDC7181 was examined a active systemic anaphylaxis (ASA) and passive cutaneous anaphylaxis (PCA) test, in guinea pig and mouse-rat models, respectively. In ASA test, IDC7181 induced the signs of restlessness in a few animals immunized with a high dose (100 mg/kg) of IDC7181 alone or in combination with Freund’s complete adjuvant (FCA). In PCA test, only one of ten sera from the animals immunized with a high dose (100 mg/kg) of IDC7181 in the absence or presence of FCA showed positive reaction. The positive reaction, induced by IDC7181, which may be due to beta-lactam ring, in ASA and PCA tests were negligible in comparison with those of traditional cephalosporins. Taken together, it is suggested that IDC7181 do not cause immunological problems in clinical dosage.
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KEYWORD
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IDC7181, Antigenicity, Active systemic anaphylaxis, Passive cutaneous anaphylaxis, Cephalosporin
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